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| Tweet Topic Started: May 4 2007, 03:12:47 PM (195 Views) | |
| ren | May 4 2007, 03:12:47 PM Post #1 |
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update:
Adding 002611+ into the mix, assuming it is a reliable point mutation as Nonaka claims, it would fall under Line1 as an immediate branch exclusive of the other branches in the below scenarios.
Given that 021345 occurs with and without M134, it would seem that it is upstream from M134. >021354 >>M134 >>>M134, M117 Given that Line1 occurs without 021345 and vice versa, it seems that they are parallel branches. >Line1 >021345 Given that 021345 occurs with or without M7, it seems that 0212345 is upstream from M7. Given that M134 does not occur with M7 and vive versa, it seem they are parallel branches below 021345. >021345 >>M7 >>M134 >>>M134, M117 The consolidated tree up to this point would be >Line1 >021345 >>M7 >>M134 >>>M134, M117 ----------------------------------------------------------------------------------------------- So far, no problem, but then we run into trouble:
Given that Line1 suddenly appears with 021345 and 021345+M7, we have to assume A), B ), or C). ----------------------------------------------------------------------------------------------- A) Line1 occurs as an insertion and then 021345 is derived from it, but than Line1 becomes a deletion, in which case you'd get 021345 without Line1 and the appearance of it as a parallel branch to the Line1 branch. In this case, Line1 could've occurred as a deletion twice, once with 021345 and once with 021345 + M7, or Line1 could be occur as a deletion once, in which case M7 is recurrent also. Scenario 1a: >Line1 >>021345 >>>021345 + Line del >>>M7 >>>>M7 + Line1 del >>M134 >>>M134, M117 Scenario 1b: >Line1 >>021345 >>>021345 + Line del >>>>021345 + Line1 del + M7 >>>M7 >>M134 >>>M134, M117[/b ----------------------------------------------------------------------------------------------- B ) Or Line1 recurred twice, once with 021345 and once with 021345 + M7: >021345 >>021345 + Line1 >>M7 >>>M7 + Line1 The consolidated tree would be, Scenario 2: >Line1 >021345 >>021345 + Line1 >>M7 >>>M7 + Line1 >>M134 >>>M134, M117 Or Line1 could have recurred only once in this case, and then M7 is also a recurrence. Scenario 3: >Line1 >021345 >>M7 >>M134 >>>M134, M117 >>021345 + Line1 >>>021345 + Line1 + M7 ----------------------------------------------------------------------------------------------- C) 021345 and M7 are recurrent mutations. If 021345 is the recurrent mutation, then M7 is also recurrent and a derivative of 021345 + Line1. Scenario 4: >Line1 >>021345 >>>021345 + M7 >021345 >>M7 >>M134 >>>M134, M117 ----------------------------------------------------------------------------------------------- -Given that Line is mentioned as an unreliable marker, than Scenario 1 is most likely. -021345 is mentioned as reliable. -Is there any mention ont he reliability of M7? -Why would Line1 keep recurring and deleting in the O3 lineage and not anywhere elese?
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